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Wednesday, April 30, 2008

Three CR Videos

I just uploaded these onto my youtube channel, enjoy;

CR MSNBC Story


Paul and Meredith Interview


CBS? Michael And April Interview

Tuesday, April 29, 2008

More Liver

It's time to celebrate your liver. It's a hard-working organ and it deserves some credit.

One of the liver's most important overall functions is maintaining nutrient homeostasis. It controls the blood level of a number of macro- and micronutrients, and attempts to keep them all at optimal levels.

Here's a list of some of the liver's functions I'm aware of:
  • Buffers blood glucose by taking it up or releasing it when needed
  • A major storage site for glycogen (a glucose polymer)
  • Clears insulin from the blood
  • Synthesizes triglycerides
  • Secretes and absorbs lipoprotein particles ("cholesterol")
  • Stores important vitamins: B12, folate, A, D, E, K (that's why it's so nutritious to eat!)
  • Stores minerals: copper and iron
  • Detoxifies the blood
  • Produces ketone bodies when glucose is running low
  • Secretes blood proteins
  • Secretes bile
  • Converts thyroid hormones
  • Converts vitamin D (D3 --> 25(OH)D3)
The liver is an all-purpose metabolic powerhouse and storage depot. In the next post, I'll give you a recipe for it...

The Liver: Your Metabolic Gatekeeper

As I've been learning more about the different blood markers of metabolic dysfunction, something suddenly occurred to me. Most of them reflect liver function! Elevated fasting glucose, low HDL cholesterol, high LDL cholesterol, high triglycerides and high fasting insulin all reflect (at least in part) liver function. The liver is the "Grand Central Station" of cholesterol and fatty acid metabolism, to quote Philip A. Wood from How Fat Works. It's also critical for insulin and glucose control, as I'll explain shortly. When we look at our blood lipid profile, fasting glucose, or insulin, what we're seeing is largely a snapshot of our liver function. Does no one talk about this or am I just late to the party here?!

I read a paper today from the lab of C. Ronald Kahn that really drove home the point. They created a liver-specific insulin receptor knockout (LIRKO) mouse, which is a model of severe insulin resistance in the liver. The mouse ends up developing severe whole-body insulin resistance, dramatically elevated post-meal insulin levels (20-fold!), impaired glucose tolerance, and elevated post-meal and fasting glucose. Keep in mind that this all resulted from nothing more than an insulin resistant liver.

LIRKO mice had elevated post-meal blood glucose due to the liver's unresponsiveness to insulin's command to take up sugar. Apparently the liver can dispose of one third of the glucose from a meal, turning it into glycogen and triglycerides. The elevated fasting glucose was caused by insulin not suppressing gluconeogenesis (glucose synthesis) by the liver. In other words, the liver has no way to know that there's already enough glucose in the blood so it keeps on pumping it out. This is highly relevant to diabetics because fasting hyperglycemia comes mostly from increased glucose output by the liver. This can be due to liver insulin resistance or insufficient insulin production by the pancreas.

One of the interesting things about LIRKO mice is their dramatically elevated insulin level. Their pancreases are enlarged and swollen with insulin. It's as if the pancreas is screaming at the body to pick up the slack and take up the post-meal glucose the liver isn't disposing of. The elevated insulin isn't just due to increased output by the pancreas, however. It's also due to decreased disposal by the liver. According to the paper, the liver is responsible for 75% of insulin clearance from the blood in mice. The hyperinsulinemia they observed was both due to increased secretion and decreased clearance. Interestingly, they noted no decline in beta cell (the cells that secrete insulin) function even under such a high load.

Something that's interesting to note about these mice is they have very low blood triglyceride. It makes sense since insulin is what tells the liver to produce it. Could this have something to do with their lack of beta cell dysfunction?

The really strange thing about LIRKO mice is that their blood glucose becomes more normal with age. Strange until you see the reason: their livers are degenerating so they can't keep up glucose production!

LIRKO mice reproduce many of the characteristics of type II diabetes, without degenerating completely into beta cell death. So insulin resistance in the liver appears to reproduce some elements of diabetes and the metabolic syndrome, but the full-blown disorders require other tissues as well. As a side note, this group also has a skeletal muscle-specific insulin receptor knockout which is basically normal. Interesting considering muscle tissue seems to be one of the first tissues to become insulin resistant during diabetes onset.

So if you want to end up like your good pal LIRKO, remember to drink high-fructose corn syrup with every meal! You'll have fatty liver and insulin resistance in no time!

I have a lot more to say about the liver, but I'll continue it in another post.

Monday, April 28, 2008

Gluten-Free Enchilada Bake: Roasted Green Chile and Cream Cheese

Easy gluten-free tortilla bake with cream cheese and green chiles.
Gluten-free tortilla bake with cream cheese and green chiles.


Planted on the coast of Cape Cod for years (forever, it seemed, on gloomy January days blanketed in gray) I daydreamed about fire roasted chiles. The smoky pepper sweetness that flirted with your senses as you walked in Santa Fe. The luxury of buying bags of freshly roasted chiles by the roadside- still warm,  soft as butter, and charred. In fact, I may have moved here for the chiles alone.

That's entirely possible.

I may have been so drop dead in love with chiles when we bought this casita that I didn't notice I'd be stuck out in the desert with so few neighbors. No bookstore, no cafe- no movie theater. What was I thinking? Only my analyst knows for sure (if she remembers me; it's been years since Jungian analysis).

Along with dreaming of Val Kilmer (not the rock scrambling Thunderheart Val, the seasoned, voluptuous new Mega Val- and why he showed up in my dream, I've no clue- better ask my analyst about that, too) I've been craving roasted green chile this month like mad as we approach our second anniversary of moving to New Mexico. 

And wouldn't you know it! I'm out of last year's roadside bags of chiles. 


They're long gone (my freezer is annoyingly, shall we say, petite). Until roasting season starts I have to settle with buying frozen Bueno chiles. And they're not bad, exactly. They are pretty dang good.

Yet, as I sit and crave and daydream, the big question becomes: Do I really still want to be here in August when chile roasting begins? Is my chile love a devoted, true love, or simply an infatuation? A passing fancy? Will your intrepid dusty goddess remain here in the coyote hills of O'Keeffe country or soon be walking Venice Beach in her Rocket Dogs?

I tell myself, just breathe.


There are Bueno chiles to defrost.

Read more + get the recipe >>

Book Review: Blood Sugar 101

I just finished reading "Blood Sugar 101" by Jenny Ruhl. It's a quick read, and very informative. Ruhl is a diabetic who has taken treatment into her own hands, using the scientific literature and her blood glucose monitor to understand blood sugar control and its relationship to health. The book challenges some commonly held ideas about diabetes, such as the notion that diabetics always deteriorate.

She begins by explaining in detail how blood glucose is controlled by the body. The pancreas releases basal amounts of insulin to make glucose available to tissues between meals. It also releases insulin in response to carbohydrate intake (primarily) in two bursts, phase I and phase II. Phase I is a rapid response that causes tissues to absorb most of the glucose from a meal, and is released in proportion to the amount of carbohydrate in preceding meals. Phase II cleans up what's left.

In a person with a healthy pancreas, insulin secretion will keep blood glucose under about 130 mg/dL even under a heavy carbohydrate load. The implications of this are really interesting. Namely, that blood glucose levels will not be very different between a person who eats little carbohydrate, and one who eats a lot, as long as the latter has a burly pancreas and insulin-sensitive tissues.

Most Americans don't have such good control however, hence the usefulness of low-carbohydrate diets. This begs the question of why we lose blood sugar control. Insulin resistance seems like a good candidate, maybe preceded by
leptin resistance. As you may have noticed, I'm starting to think the carbohydrate per se is not the primary insult. It's probably something else about the diet or lifestyle that causes carbohydrate insensitivity. Grain lectins are a good candidate in my opinion, as well as inactivity.

Diabetics can have blood glucose up to 500 mg/dL, that remains elevated long after it would have returned to baseline in a healthy person. Ruhl asserts that elevated blood sugar is toxic, and causes not only diabetic complications but perhaps also cancer and heart disease.


Heart attack incidence is strongly associated with A1C level, which is a rough measure of average blood sugar over the past couple of months. It makes sense, although most of the data she cites is correlative. They might have seen the same relationship if they had compared heart attack risk to fasting insulin level or insulin resistance. It's difficult to nail down blood sugar as the causative agent. More information from animal studies would have been helpful.


Probably the most important thing I took from the book is that the first thing to deteriorate is glucose tolerance, or the ability to pack post-meal glucose into the tissues. It's often a result of insulin resistance, although autoimmune processes seem to be a factor for some people.
Doctors often use fasting glucose to diagnose diabetes and pre-diabetes, but typically you are far gone by the time your fasting glucose is elevated!

I like that she advocates a low-carbohydrate diet for diabetics, and lambasts the ADA for its continued support of high-carbohydrate diets.

Overall, a good book. I recommend it!

Saturday, April 26, 2008

Strawberry Chocolate Chip Scones- Gluten-Free Recipe

Gluten free scones with strawberries and chocolate chips
Easy gluten-free scone deliciousness.

Today was a good day. A strawberry and chocolate laced crusty on the outside tender on the inside kind of day. That's right. I got sconed. And the best part (aside from the fresh organic berry goodness, that is)? These golden biscuity morsels are vegan. That's right. No eggs. No milk. No butter (sorry, moo-cow fans).

On a whim yesterday (I am often prone to whims Dear Reader, especially after a sun dappled picnic on the Santa Fe plaza, perched on a bench beneath a flowering cherry tree across from a red robed Buddhist monk eating Chinese take-out. We devoured pesto slathered smoked turkey rolled in brown rice tortillas and I didn't drip a single green drop of cilantro infused olive oil on my ironed boot cut jeans) I picked up a Gluten-Free Pantry Muffin and Scone Mix at Whole Foods (long time readers know I miss my old favorite Pamela's Ultimate Baking Mix, and I've yet to find an all-purpose replacement mix that's half as good).

I was in such an expansive mood post my double espresso at the nearby Starbucks that I thought I might try baking something fun and slightly indulgent for the weekend. The organic strawberries smelled beyond heavenly in their ripe and ruby lusciousness. Yes, I smell all my fruit and veggies before I buy. Don't you? The woman with the amber handled cane you see standing in the Whole Foods produce aisle sniffing tomatoes and berries and anything else she can get her one free hand on, Darling?

That would be me.

Read more + get the recipe >>

Monday, April 21, 2008

Gluten-Free Salad Dressing Recipes: Or 3 Ways To Dress A Naked Salad

Gluten free salad dressings for your fresh crisp greens
Three easy gluten-free salad dressings.


Let us take a moment and appreciate the humble green salad. The crisp crunchy greenness. The tender bites of bitter and sweet. The whole feel-good shiver you get when you chow down a plate of bunny food.

Bunny food rocks, my friend.

But how to dress a naked green? That is the question. Bottled stuff simply won't do. Too many additives and stabilizers and gums you can't pronounce. Or the ubiquitous evil soybean oil. Ick. (Did I just write Ick? Well, I meant it. I loathe soybean oil.) I offer you, instead, three simple dressings- three recipes you can whip up in a New Mexico minute, adapted from my first cookbook, Recipes from a Vegetarian Goddess. Toss them with love.


Basil Citrus Vinaigrette


This a perfect dressing for a brunch salad- especially if you're serving Mimosas.

Ingredients:

4 tablespoons extra virgin olive oil
2 tablespoons fresh orange juice
2 tablespoons Champagne vinegar
1 teaspoon orange zest
2 tablespoons minced fresh basil
1/2 teaspoon organic agave nectar
A pinch of sea salt, to taste
Fresh ground pepper, to taste

Mix all of the ingredients in a glass dish or cup. I use a fork for this. Drizzle over fresh greens. Toss. Munch. Be happy.

Serves 4.


Ginger Dressing


The Asian flavors in this include soy sauce- if you're allergic to soy try substituting molasses.

Ingredients:

2 tablespoons sesame oil
1 tablespoon light olive oil
4 tablespoons rice vinegar
2 tablespoons wheat-free soy sauce
1 inch fresh ginger, grated
1 garlic clove, minced
1/2 teaspoon organic agave nectar

Mix all of the ingredients in a glass dish or cup. I use a fork for this. Taste test and adjust seasonings.

Pour over an Asian-inspired mix of spring greens, matchstick carrots, sliced water chestnuts, mung bean sprouts, sliced mushrooms, red onion and cashews. Toss. Smile.

Serves 4.


Greek Salad Dressing


Greek salad makes an easy weeknight supper. Pair it with a hearty bread like my Sweet Potato Cornbread. Add in some hard boiled eggs, sardines or tuna if you like.

Ingredients:

4 tablespoons extra virgin olive oil
2 tablespoons fresh lemon juice
2 tablespoons golden balsamic vinegar
1 teaspoon lemon zest
1 tablespoon minced fresh oregano
1 tablespoon minced fresh mint
1 clove garlic, minced
1/2 teaspoon organic agave nectar
A pinch of sea salt, to taste
Fresh ground pepper, to taste

Mix all of the ingredients in a glass dish or cup. I use a fork for this. Taste test and adjust seasonings.

Drizzle over a Greek salad that includes cucumbers, red onion, kalamata olives, pepperoncini, grape tomatoes and feta cheese. Toss. Devour. Dance. Smash a few plates.

Serves 4.


Recipe Source: glutenfreegoddess.blogspot.com

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Thursday, April 17, 2008

Olive Oil Buyer's Guide

Olive oil is one of the few good vegetable oils. It is about 10% omega-6 (n-6) fatty acids, compared to 50% for soybean oil, 52% for cottonseed oil and 54% for corn oil. Omega-6 fatty acids made up a smaller proportion of calories before modern times, due to their scarcity in animal fats. Beef suet is 2% n-6, butter is 3% and lard is 10%. Many people believe that excess n-6 fat is a contributing factor to chronic disease, due to its effect on inflammatory prostaglandins. I'm reserving my opinion on n-6 fats until I see more data, but I do think it's worth noting the association of increased vegetable oil consumption with declining health in the US.

Olive oil is also one of the few oils that require no harsh processing to extract. As a matter of fact, all you have to do is squeeze the olives and collect the oil. Other oils that can be extracted with minimal processing are red palm oil (9% n-6), hazelnut oil (10% n-6) and coconut oil (2% n-6). These are also the oils I consider to be healthy. Due to the mild processing these oils undergo, they retain their natural vitamin and antioxidant content.

You've eaten corn, so you know it's not an oily seed. Same with soybeans. So how to they get the oil out of them? They use a combination of heat and petroleum solvents. Then, they chemically bleach and deodorize the oil, and sometimes partially hydrogenate it to make it more shelf-stable. Hungry yet? This is true of all the common colorless oils, and anything labeled "vegetable oil".


Olive oil is great, but don't run out and buy it just yet! There are different grades, and it's important to know the difference between them.
The highest grade is extra-virgin olive oil, and it's the only one I recommend. It's the only grade that's not heated or chemically refined in any way. Virgin olive oil, "light" olive oil (refers to the flavor, not calories), "pure" olive oil, or simply olive oil all involve different degrees of chemical extraction and/or processing. This applies primarily to Europe. Unfortunately, the US is not part of the International Olive Oil Council (IOOC), which regulates oil quality and labeling.

The olive oil market is plagued by corruption. Much of the oil exported from Italy is
cut with cheaper oils such as colza. Most "Italian olive oil" is actually produced in North Africa and bottled in Italy, and may be of inferior quality. The USDA has refused to regulate the market so they get away with it. If you find a deal on olive oil that looks too good to be true, it probably is.

Only buy from reputable sources. Look for the IOOC seal, which guarantees purity, provenance and freshness. IOOC olive oil must contain less than 0.8% acidity. Acidity refers to the percentage of free fatty acids (as opposed to those bound in triglycerides), a measure of damage to the oil.
Fortunately, the US has a private equivalent to the IOOC, the California Olive Oil Council (COOC). The COOC seal ensures provenance, purity and freshness just like the IOOC seal. It has outdone the IOOC in requiring less than 0.5% acidity. COOC-certified oils are more expensive, but you know exactly what you're getting.

Thanks to funadium for the CC photo

Tuesday, April 15, 2008

Real Food V: Sauerkraut

Sauerkraut is part of a tradition of fermented foods that reaches far into human prehistory. Fermentation is a means of preserving food while also increasing its nutritional value. It increases digestibility and provides us with beneficial bacteria, especially those that produce lactic acid. Raw sauerkraut is a potent digestive aid, probably the reason it's traditionally eaten with heavy food.

Sauerkraut is produced by a process called ‘anaerobic’ fermentation, meaning ‘without oxy
gen’. It’s very simple to achieve in practice. You simply submerge the cabbage in a brine of its own juices and allow the naturally present bacteria to break down the sugars it contains. The process of ‘lacto-fermentation’ converts the sugars to lactic acid, making it tart. The combination of salt, anaerobic conditions, and acidity makes it very difficult for anything to survive besides the beneficial bacteria, so contamination is rare. If it does become contaminated, your nose will tell you as soon as you taste it.

Store-bought sauerkraut is far inferior to homemade. It's soggy and sterile. Ask
a German: unpasteurized kraut is light, crunchy and tart!

My method is inexpensive and requires no special equipment. I've tested it many times and have never been disappointed.


Materials
  • Wide-mouth quart canning jars (cheap at your local grocery store)
  • Beer bottles with the labels removed, or small jars that fit inside the canning jars
  • Three tablespoons of sea salt (NOT iodized table salt-- it's fatal to our bacteria)
  • Five pounds of green cabbage
Recipe
  1. Chop cabbage thinly. Ideally the slices should be 2 mm or so wide, but it doesn’t matter very much. You can use a food processor, mandolin or knife.
  2. Put all the cabbage together in a large bowl and add the salt. If the salt is not very dense (sometimes finely ground sea salt can be fluffy), you can add up to 5 tablespoons total. Mix it around with your hands. Taste some. It should be good and salty.
  3. Let the salted cabbage sit in the bowl for 30 minutes or so. It should be starting to get juicy.
  4. Pack the cabbage tightly into the canning jars. Leave 2-3 inches at the top of the jar. When you push on the cabbage in the jar, you should be able to get the brine to rise above the cabbage. Try to get rid of air bubbles.
  5. Put water into the beer bottles and place them into the canning jars. The weight of the bottles will keep the cabbage under the brine. It’s okay that some of the brine is exposed to the air; the cabbage itself is protected.
  6. Let it sit for 2 weeks at room temperature! As the fermentation proceeds, bubbles will form and this will raise the level of the brine. This is normal. You might get some scum on top of the liquid; just check for this and scrape it off every few days. It won’t affect the final product. If the brine drops to the level of the cabbage, add salt water (1 tsp/cup, non-chlorinated water) to bring it back up.
  7. Taste it! It should be tart and slightly crunchy, with a fresh lactic acid flavor. If fully fermented, it will keep in the fridge for a long time.
Here are some photos from making sauerruben, which is like sauerkraut but made with turnips:


Monday, April 14, 2008

What I miss? My Blue Corn Chip Frittata

Frittata- an easy, gluten-free supper.


There are nights when tossing together breakfast for dinner is the sane thing to do. It's easy. It's fast. And yes, even delicious. A well done frittata is bliss, pure and simple. Here is one of my old favorites.

Blue Corn Chip Frittata for Two

Choose fresh free-range organic eggs for best taste. The chips can be a tad stale.

Ingredients:

Organic blue corn chips- enough for one layer in an omelette pan
2 tablespoons Roasted Vegetable Salsa
2-3 oz. Jalapeño Pepper Jack or cheddar cheese, shredded
4 large organic free-range eggs
1/3 to 1/2 cup light cream or Half & Half
A few organic grape or cherry tomatoes, halved
Fresh chopped cilantro

Instructions:

Preheat the oven to 375ºF.

Lightly oil an oven proof 8-inch omelet pan.

Layer the blue corn chips in the bottom of the prepared pan. Top each chip with a dab of salsa. Sprinkle with most of the shredded cheese.

Whisk the eggs with the cream till fluffy and pour the mixture all over the chips. Finish with the rest of the cheese. Top with the halved tomatoes and a dusting of fresh cilantro.

Bake in a hot oven for about 20 to 25 minutes or until the eggs are set and the frittata is golden.

Serves 2. 


Serve with Joey's Kicked Up Rockin' Guac.






Saturday, April 12, 2008

Gluten-Free Tomato Soup

A yummy tomato soup with a secret. Shhh!

Sneaky Tomato Soup


A old school family favorite- tomato soup. Right? Here's an easy kid-friendly recipe. With a secret. When I was a little girl cabbage was a stinky word. Cabbage was something you wrinkled your nose at. The mere mention of the word conjured the smell of my grandmother's house- which was, in truth, an olfactory bouquet of Lucky Strikes, boiled eggs and kielbasa. Cabbage was only the top note. And how I hated it.

In those golden culinary days of the 1950's and '60's, the favored method of cooking cabbage was to boil it to death. Often, with potatoes. And apparently without opening the windows. Come to think of it- I don't ever remember seeing an open window in my grandmother's house. I have no images of curtains sailing upward in a gusty cool spring breeze. No sense memories of distant humming lawnmowers to distract from the television. No conjuring of fresh air. Was this lock-down by some unseen divine plan? Or maybe a generalized exercise in denial? Who knows?

All I knew was that the end result of the boiling-cabbage-to-death method was rather like eating swampy unidentified mush. Not exactly tantalizing for a texture and fragrance sensitive child. Why would anyone eat this? my tiny girl heart would question. Because it's good for you, was the inevitable answer.

Turns out, of course (and you knew this was coming), cabbage is, indeed, very good for you. Especially for those of us healing from the ravages of celiac disease. Cabbage, it turns out, heals the gut. So, what if your childhood included smelly bowls of boiled cabbage and you simply can't make yourself- or someone you love with all of your buoyant and hopeful heart- eat the damn stuff? Bubela. 

Have I got a soup for you.

Read more + get the recipe >>

Tuesday, April 8, 2008

Gluten-Free Pueblo Bread Recipe with Green Chiles

Gluten-Free Pueblo Bread with Green Chiles
 Rustic gluten-free bread- easy and delicious.

This is the easiest yeasted bread you'll ever make. Well, from a scratch recipe, I mean. You'll have to whisk together some gluten-free flours and proof a little yeast in warm (not too hot!) water, but you can handle that, right? Once it's stirred together, you smooth it into a cake pan, let it rise in a warm and cozy oven, then bake it. If you want an easier bread making experience than this, Darling, buy any gluten-free mix, dump it into a bread machine and press Start.

I'm calling it Pueblo Bread because a certain savvy friend of mine (you know the one- my pal Joey, who makes the best damn guacamole recipe this side of the Mississippi) who knows from Nuevo Native American cuisine, called it (and my quote could be slightly inaccurate, Gentle Reader, due to consuming literal fistfuls of organic hand-popped popcorn to quell the mind-numbing boredom of enduring two and half hours of There Will Be Blood), Tasty and authentic, and not unlike the local Pueblo style breads.

As for the movie choice? My bad. Maybe the sheer Shakespearean brilliance of Deadwood has spoiled me forever when it comes to period westerns (it's possible).

Next time I'm picking something with Frances McDormand.

The men will just have to deal.

Read more + get the recipe >>

Monday, April 7, 2008

Leptin

I've been puzzled by an interesting question lately. Why is it that certain cultures are able to eat large amounts of carbohydrate and remain healthy, while others suffer from overweight and disease? How do the pre-industrial Kuna and Kitavans maintain their insulin sensitivity while their bodies are being bombarded by an amount of carbohydrate that makes the average American look like a bowling ball?

I read a very interesting post on the Modern Forager yesterday that sent me on a nerd safari through the scientific literature. The paper that inspired the Modern Forager post is a review by Dr. Staffan Lindeberg. In it, he attempts to draw a link between compounds called lectins, found in grains (among other things), and resistance to the hormone leptin. Let's take a step back and go over some background.

One of the most-studied animal models of obesity is called the "Zucker" rat. This rat has a missense mutation in its leptin receptor gene, causing it to be nonfunctional. Leptin is a hormone that signals satiety, or fullness. It's secreted by fat tissue. The more fat tissue an animal has, the more leptin it secretes. Normally, this creates negative feedback that causes it to eat less when fat begins to accumulate, keeping its weight within a narrow range.

Zucker rats secrete leptin just fine, but they lack leptin receptors in their brain. Their blood leptin is high but their brain isn't listening. Thus, the signal to stop eating never gets through and they eat themselves to morbid obesity. Cardiovascular disease and diabetes follow shortly thereafter, unless you remove their
visceral fat surgically.

The reason Zucker rats are so interesting is they faithfully reproduce so many features of the disease of civilization in humans. They become obese, hypometabolic, develop insulin resistance, impaired glucose tolerance, dyslipidemia, diabetes, and cardiovascular disease. Basically, severe metabolic syndrome. So here's a rat that shows that leptin resistance can cause something that looks a whole heck of a lot like the disease of civilization in humans.

For this model to be relevant to us, we'd expect that humans with metabolic syndrome should be leptin-resistant. Well what do you know, administering leptin to obese people doesn't cause satiety like it does in thin people. Furthermore, elevated leptin
predicts the onset of obesity and metabolic syndrome. It also predicts insulin resistance. Yes, you read that right, leptin resistance may come before insulin resistance.

Interestingly enough, the carbohydrate-loving Kitavans don't get elevated leptin like europeans do, and they don't become overweight, develop insulin dysfunction or the metabolic syndrome either. This all suggests that leptin may be the keystone in the whole disease process, but what accounts for the differences in leptin levels between populations?



Friday, April 4, 2008

Hydration: Attempt Only Under Medical Supervision

I've noticed how the word "hydration" has crept into the popular lexicon in the last decade or so. Before that, we were so primitive, we just "drank water". Now you need a PhD just to put a glass to your lips. I'm not sure I'm qualified!

I've been hearing so many people, including health professionals, tell me to drink 8 glasses of water a day for my entire life. In my middle school health class, I was told by my hydrophilic teacher that I should be urinating every hour and my urine should always be clear. For my whole life, I've thought it was nonsense. Yet the message has reached people. Walk around any college campus and you'll see undergrads faithfully carrying around their endocrine-disrupting plastic-water everywhere they go.

You see, our bodies have this very sophisticated mechanism to ensure water homeostasis. It's called thirst. If we need so much water to be healthy, why aren't we thirsty more often?

I skimmed through a paper today in the Journal of the American Society of Nephrology that reviews the evidence for health benefits from drinking more water than your thirst demands. Their conclusion: there's no evidence to suggest it helps anything. Water is just a nice harmless placebo.

The term "hydration" has helped fuel a whole industry to satisfy our need for hydration technology. Gatorade claims it hydrates better than water. It must be the high-fructose corn syrup and yellow #5... And make sure to bring your "hydration pack" when you go on your 20 minute jog; you might get lost and end up in the Kalahari desert!

I actually think the water craze isn't totally harmless. Drinking large amounts of water with a meal interferes with digestion by diluting digestive enzymes and stomach acid. Drinking a tall beer does the same. Wine is better because it tends to be a smaller volume.

As far as I'm concerned, with minor exceptions, the only thing to drink is water. I'll have an occasional glass of wine, beer or whole raw milk, but 99% of what I drink is good old-fashioned dihydrogen oxide.

The only time I drink a large amount of water without being thirsty is if I'm about to do vigorous exercise or spend time outside in hot weather.

Thanks to Snap for the CC photo.

Wednesday, April 2, 2008

Low-carb Review Article

The other day, I came across this nice review article from the American Journal of Clinical Nutrition. It gives a thorough but accessible overview of the current state of research into carbohydrate-restricted diets, without all the fatophobic mumbo-jumbo. It points out a few "elephants in the room" that the mainstream likes to ignore. First of all, the current approach isn't working:
The persistence of an epidemic of obesity and type 2 diabetes suggests that new nutritional strategies are needed if the epidemic is to be overcome.
They claim that preagricultural diets were low in carbohydrate:
In contrast to current Western diets, the traditional diets of many preagricultural peoples were relatively low in carbohydrate (1, 2). In North America, for example, the traditional diet of many First Nations peoples of Canada before European migration comprised fish, meat, wild plants, and berries. The change in lifestyle of several North American aboriginal populations occurred as recently as the late 1800s, and the numerous ensuing health problems were extensively documented (3-5). Whereas many aspects of lifestyle were altered with modernization, these researchers suspected that the health problems came from the change in nutrition—specifically, the introduction of sugar and flour.
But of course, many of them were very high in carbohydrate, and these cultures seemed in fine health as well.

Carbohydrate reduction leads to a normalization of appetite:
It may also be that the mere lowering of serum insulin concentrations, as is seen with LCDs, may lead to a reduction in appetite. In support of this idea, several studies have found that insulin increases food intake, that foods with high insulin responses are less satiating, and that suppression of insulin with octreotide leads to weight loss (27-29).
I can't believe it; all that fat isn't going to clog my arteries??
Several outpatient diet studies have shown reductions in CVD risk factors after an 8–12-wk LCKD, during weight loss, and during weight maintenance (21, 60-62).
The last paragraph is a zinger:
We emphasize that strategies based on carbohydrate restriction have continued to fulfill their promise in relation to weight loss and that, contrary to early concerns, they have a generally beneficial effect on most markers of CVD, even in the absence of weight loss. In combination with the intuitive and established efficacy in relation to glycemic control in diabetics, some form of LCD may be the preferred choice for weight reduction as well as for general health.

Tuesday, April 1, 2008

Quick and Easy Sesame Shrimp Stir-Fry

Easy sesame shrimp stir-fry on rice.

I was stir-frying last night. I know. Big YAWN. No big whup. B-o-r-i-n-g.

But what you don't know? That despite the hefty gusts of juniper pollen thickened wind battering the casita (hefty gusts of juniper pollen thickened wind makes me downright prickly if not certifiable) I managed to gather my dull, throbbing wits long enough to create a new stir-fry sauce.

For you, Dear Reader.



JUNIPER ASSAULTED GODDESS
(chewing)

So. What do you think? On a scale of one to ten?

PATIENT KIND HUSBAND
(scraping bowl spotless)

Um. Really, really tasty. Eleven. And a half.

JUNIPER ASSAULTED GODDESS
(blowing pollen thickened nose)

Really? Wow. Wait.
(pause)
It's not a twelve?





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