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Wednesday, May 30, 2007

New photo section - matt aging

Click HERE to see some photos. There are some more I want to put up, but can't right now. Howver, there are pictures there of me at 11, 15, 19, 21, 22, 22-8m old. One of them is taken with some of my cousins, anthony on the right is the same age as me but was HUGE compared to my tiny frame lol. The one at disney is me and my sister, she is about 2 years younger than me.

EDIT: Oh yes, I forget... I'm going to get my cholesterol checked on friday. Its been almost a year so hopefully I see an improvement in HDL from the increased take of EVOO.

Monday, May 28, 2007

Adiponectin ^ SIRT1 > Healthier aging?

I posted a paper on centenarians a while back on the CR lists suggesting that Adiponectin is worth measuring in long term calorie restrictors. I’m unaware that this has been measured at WUSTL? If it was could you share the results? Anyway, an old paper on centenarians looked at various aspects of their health, and it hypothesised that adiponectin plays a crucial role in the their health and longevity of these centenarians. They had three groups and only the centenarians had a statistically significant higher level of this adipocytokine, despite have a control group who were around the same BMI. From Paper [1] “Mean concentration of plasma adiponectin in female centenarians was almost twice as high as those in BMI-matched female controls (20.3 ± 7.4, 10.8 ± 3.9, P < 0.001, respectively), and also higher than those in elderly controls (P < 0.001)”. SIRT1 wasn’t actually measured in this study but [2] shows that Adiponectin induces expression of the SIRT1 Protein. There could be a possibility that because of the significantly higher level of adiponectin, these centenarians also had higher levels of SIRT1, (which is thought to be important in mammalian aging) and thus increased longevity. Centenarians also maintained a low BMI, but this could be the fact that they were suffering from age related muscle loss, as what happens with age. Although in the case of CR, it is sort of attenuated, in rodents at least. Calorie restriction is also thought to increase adipoectin in both rodents and humans under calorie restriction, and even those that have AN.


[1]Yasumichi Arai,1 Susumu Nakazawa,1 Toshio Kojima,3 Michiyo
Takayama,1 Yoshinori Ebihara,1 Ken-ichirou Shimizu,5 Ken Yamamura,1 Satoki Homma,1 Yasunori Osono,6 Yasuyuki Gondo,2 Yukie Masui,2 Hiroki Inagaki,2 Kohji Kitagawa4 and Nobuyoshi Hirose1 High adiponectin concentration and its role for longevity in female centenarians Geriatr Gerontol Int 2006; 6: 32–39


[2] Anthony E. Civitarese*, Stacy Carling, Leonie K. Heilbronn,
Mathew H. Hulver, Barbara Ukropcova, Walter A. Deutsch, Steven R. Smith, Eric Ravussin Calorie Restriction Increases Muscle Mitochondrial Biogenesis in Healthy Humans
PLoS Med. 2007 Mar 6;4(3):e76
PMID: 17341128

Sunday, May 27, 2007

Super Centenarians

VIDEO:
CNN: Gupta on Super Centenarians

This is from a few months ago but thought I'd post it, as I don't have much time to post anything else right now. The women in this video is 112 years old. She didn't smoke or drink all her life and took care of herself...

The scientist mentions that in general, super centenarians look younger at all stages of life and function much younger than their age. Researchers attribute reaching these ages purely on genetics, but I have a feeling that depending on where in the world you look, different influences on getting to these ages will turn up. For example, in the U.S, its more likely to be genetics, as there are fewer centenarians than say japan. Where in particular Okinawa is thought to be more diet related.

Calorie Restriction seems to give the majority of its followers characteristics similar to long lived people. Lower body temperature, extremely good insulin sensitivity, and hopefully slower declining DHEA-S, lower levels of oxidative damage, better DNA repair and more. If you look up the evidence that is SLOWLY being found from centenarian studies you will see that the theories or details on why these people might reach such ages are pretty much also influenced by calorie restriction. We could argue that some long term CRers do in fact look a little younger than their ages too. Whether or not we push 120 years is very much up for debate, but I think our chances of reaching 100 is MANY times greater than the general population. It could just be that 'super centenarians' experience the longevity that would be possible on a CR diet (but they didn't do CR). So because the population is so big, the chances of genes influencing lifespan, how CR influences lifespan could be likely possibility.

This is interesting, it's from the Baltimore study on aging. As I said above, CR influences all three markers. So it seems average lifespan should at least be extended. I think assuming that Life long Calorie Restriction will only give 1-2 years extra life as a few researchers are saying is extremely pessimistic. Especially since we know how long certain groups of people live longer, one comes to mind is Seventh Day adventists, and they don't even do calorie restrction. This is quite obvious as various studies have shown their average BMI to be around 24 (ref 18.5-25). And the men live upto 9-10 years longer than the average american. This is just by eating a healthy diet!

Below: Men that show the same characteristics influenced by CR live longer (without CR).

Savory Grain-Free Crackers

Gluten free cheese crackers with garlic
Gluten-free grain-free crackers.

 

As promised, here is how I made the grain-free gluten-free crackers I took with me to the set of The Canyon. This is a fairly simple recipe with delicious results. A savory garlicky grain-free cracker made with almond meal. Enjoy!

Karina's Savory Grain-Free Cracker Recipe

Originally published May 2007.

These crackers are mighty tasty- especially if you're generous with the seasonings. I used Trader Joe's Roasted Garlic and Organic Italian Herbs to create kick-ass flavor.

Ingredients:

2 cups almond meal
1 teaspoon baking soda
1 teaspoon minced roasted garlic, to taste
Pinch of dried minced onion
2 teaspoons dried Italian Herbs, to taste
Pinch or two of turmeric or paprika for color
1 teaspoon of fine sea salt
1 teaspoon sugar or raw organic agave
1 cup very finely grated aged Parmesan (I used a microplane grater)
2 tablespoons extra virgin olive oil
4 tablespoons spring or filtered water, as needed
1 beaten egg white- or omit for vegan

Instructions:

Preheat the oven to 350ºF. Line a standard baking sheet with parchment paper or a reusable Silpat.

Combine the ingredients in a mixing bowl and stir until a moist, moderately sticky dough forms. Add more water or oil if you need it.

Taste test. Adjust seasonings to your taste buds. If it needs it, add a tiny pinch of sugar to offset the salty flavor.

Using oiled hands place the mound of dough on the parchment and flatten with the palm of your hand. Use oiled palms and fingers to press the dough out evenly and quite thin. If it cracks, simply press back together with moist fingers.

Bake in the center of a hot oven for 15 minutes or until the dough is set and golden.

Remove and cool on a wire rack. When the dough has cooled, cut the dough into pieces using a pizza cutter. Or break apart for random jagged pieces.

The crackers will be extremely tender and breakable while they are warm. Allow them to cool completely before handling.

Store in an air tight container. They are not super crisp, and are quite tender. And best of all- very flavorful.

If you prefer a crisper cracker, bake briefly before serving. Keep an eye on them so that they don't get too browned.

This made roughly 18 crackers.



Recipe Source: glutenfreegoddess.blogspot.com

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Tuesday, May 22, 2007

CR article and Vitamin D!

Michael Rae posted this CR article on the CRS lists today. He was interviewed a while back he said in the email.

Interview with Michael Rae. Six feet tall, 115 lb., and talking about eating less and living longer. KENNETH WHYTE


A good read anyway...

Another good article is this one

The Antibiotic Vitamin

In April 2005, a virulent strain of influenza hit a maximum-security forensic psychiatric hospital for men that's midway between San Francisco and Los Angeles. John J. Cannell, a psychiatrist there, observed with increasing curiosity as one infected ward after another was quarantined to limit the outbreak. Although 10 percent of the facility's 1,200 patients ultimately developed the flu's fever and debilitating muscle aches, none did in the ward that he supervised.

"First, the ward below mine was quarantined, then the wards on my right, left, and across the hall," Cannell recalls. However, although the 32 men on his ward at Atascadero (Calif.) State Hospital had mingled with patients from infected wards before their quarantine, none developed the illness.


Amazing!

There was also another article on Vitamin D and TB the other week

Scientists have shown that a single 2.5mg dose of vitamin D may be enough to boost the immune system to fight against tuberculosis

There has been a lot of talk and research on the fole of Vitamin D3 on health in recent years and months. If you do a quick google search every few days theres usually always something new. I think around october time I'm goin to start supplementing at least 4000-5000IU of vitamin D3. Toxicity ranges are MUCH HIGHER than this dose. We typically make around 10,000+ just by going outdoors for around 30 minutes on summers day!

Shopping :)

Finally went food shopping, thanks agains to the two people that helped out! It was so nice of you :) It helped me avoid that junk food =/



So these are just a few things I bought, I kept a little bit of money just incase I need to pick up anything in the next few days

I bought:

Kale
almonds
2 bananas
Apples
Yeo valley organic bioactive plain yogurt
Sweet potatoes
Red Onions
Kale
Cauli (frozen)
broccoli (frozen)
green beans (frozen)
spinach (frozen)
Blueberries frozen
Tomatoes on vine
Ginger
Lindt 85% dark chocolate (50p!)

I also have a few things I bought the other day

Carrots
EVOO
Kale
Garlic
4 canned of beans (very low salt and sugar)

I must say I'm doing so well lately, I think its been around almost 4-5 weeks since my temperature returned to normal, I started to feel great. I still have no anxiety at all, I seem to be smiling all day, others can notice that I'm much happier and healthy too. I can concentrate better than ever and I feel so good, its hard to describe :D I FEEL so healthy!!! FINALLY! I knew things would work out. Now just gotta get one last problems sorted, which I have an appointment on the 4th with an ENT doctor. Its much more controlled now i'm using the Neti pot though.

I'm going to ask my doctor for a cholesterol test sometime this summer, my last one showed that my HDL decreased slightly, but total cholesterol was 109mg/dl and LDL at 58mg/dl. So pretty good, even for my age. When I get my grant I'm THINKING about getting a glucose monitor. I really want to understand exactly what my meals are doing to my glucose levels at the moment. Going to see student services this friday to check if I can get my grant now as my attendence has been 100% since I've been feeling better.

Life may well be a bowl of cherries. So eat, already!



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Goddess forbid.

And while we're at it?

The people, coyotes, various insects, cholla, snakes, skateboarding bulldogs, movie sets and circumstances depicted on this blog are the product of creative imagination and any resemblance to any actual person, coyote, insect, cholla, snake, bulldog, place or thing, whether living, dead (or only mostly dead) is purely coincidental.

Now go eat a bowl of cherries (unless, of course, you have been instructed by medical professionals to avoid eating said cherries; in that case forget the cherries; just say no to cherries; forget we ever mentioned cherries).

Are we cool-de-la?

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Monday, May 21, 2007

All done -- almost!

Last week left at college, well actually it officially ends around 29th june... but a lot of classes are finished now as we've completed all the units for this year. I just been organising the rest of my work. I have hundreds of papers which are completely spread out all over my room. Next time I need to be just a bit more organised :)

Over the summer I hope to get back to learning Spanish as I set out to do a while back. Its just I never had time this year as I've been swamped with college stuff and work. I also want to dive back into studying Cell Biology. I bought "Molecular Biology of the cell 4th edition" - Excellent book! but quite complicated and a lot to take in. Extracting and storing the most relevant stuff is quite a task. Although this will be critical for medical school. I'm going to have carry on learning to prepare for next year also, I need to work on my Maths especially. Its not that I don't like it or find it really hard... its just I never bothered at all during high school, so while others had around 5 years of learning during that time, I only spent a few months actually revising. Its quite a turn I took after reading Ray Kurzweils books. He completely changed my life for the better.

Anyway I going to cook some food now. Thank you so much to those who helped out I really appreciate it so much.

Good day 2 all :)

Friday, May 18, 2007

CR reading

I was looking around the AOR website to see what stuff they have these days... also check out some of their articles because they're quite good. Seen one which is about CR, maybe MR wrote it as it was back in 2003. When I have some time after I get this college work out of the way, i'll be posting up lots of articles on CR, and interviews with CRers on my website.

Get it here

Tuesday, May 15, 2007

CR'd - like it or not

As I've had no work over the last few weeks, college not authorising my grant because of attendence (re-evaluated at end of may), i've basically been living on around £5 a week for 3 weeks. So I've been portioning out food for myself, only its about to run out with the next couple days. So now what do I do? lol. I've gotta try and make the following last around 10 days. I get paid next friday because I work wednesday, thursday and saturday this week, and all next week. The problem is i'm doing a full time college course, so no benefits allowed. Work is usually reliable but there has been no surveys to do recently.

Wholemeal bread (around 20 slices each at 93k/cal each)
Olive oil (around 40g left in bottle)
14g almonds
250g of quaker oats
tomato sauce (half a bottle)
Two tubs of essential mix
800g of broccoli (frozen)
400g of cauli (frozen)
100g of green beans (frozen)
80g of baby carrots (frozen)
200g of peas (frozen)
30~ 25g servings of Whey protein powder
2/3 of a bottle of Cod Liver Oil / Fish Oil
1 130g canned tuna
Skim milk
3 green tea bags


I was just using beans everyday but have ran all out of that. Its useful in these situations because it has lots of protein and is a good low gi food and energy dense.

However, there is plenty of junk food here of course. Do I really want to touch that? no... but somehow I've gotta either become a little more CR'd to around 1500k/cal a day for around until the 25th or eat all junk food. I can easily meet almost every nutrient by taking higher dose of my essential mix. Of course there is other less than adequate cereals available that I can eat like wheatabix, they're Ok ish I suppose. I've also increased whey protein to 3 servings a day.

ARGHHHHHHHHHHHHHHHHHHHH

Thursday, May 10, 2007

CR website and other...

I've added a whole bunch of media on my website. Most are direct links to the videos... some I've already posted on here but not all. See them here

I thought I was going to be ill agains yesterday. Its coming to the end of college year and a lot of rushing around trying to get things organised. So I only managed around 4 hours sleep tuesday night, then on wednesday I thought I was getting a cold because it seems to be going around right now. However, this time I got a mild soar throat with that feeling of 'im going to be ill'. Then went to sleep and woke up without any sign of a cold :) Very similar to what I experienced in my first 1.5 years of CR, where I would have the start of some cold symptoms, then it would go away and never last more than a few hours. Summer holidays are nearly here, then I'll have some time to recharge, to have lots of rest and let my immunity to build up again. That college is a perfect place to catch nasty viruses and stuff.

Tuesday, May 8, 2007

Ending Aging

Ending Aging: The Rejuvenation Biotechnologies That Could Reverse Human Aging in Our Lifetime can be pre ordered on amazon now!

Authors include Aubrey De Grey and Michael Rae. If anyone is interested in the science and technologies that will enable us to finally deal with aging, then pick up this book. I'm ordering my copy when I get home from college :)

Monday, May 7, 2007

Gluten-Free Buttermilk Flatbread- Easy as 1-2-3

The easiest gluten-free cracker-flatbread ever.

There are days when keeping a Gluten-Free Pantry Quick Mix in your cupboard can come in handy. Yesterday- as the flannel grey sky spit snow at us out here in the high desert- a certain gluten-free goddess had a casita full of men to feed- including those devilishly handsome amigos of mine, Joey and Will. So Joey and I collaborated in my tiny blue tiled cocina and whipped up some tasty gluten-free comestibles.

He made his fabulous
Kicked Up Rockin' Guac. I made some hummus spiked with cilantro pesto. We served up an array of crudities, organic blue corn chips and salsa, chicken salad (from Will), my Pecan Crackers, jalapeno-stuffed olives, and my freshly made basil-pecan pesto with a spur-of-the-moment improvthat is a cross between a tender cracker and a tasty flatbread.

And I'm also thinking, Dear Reader, this dough might make for a delicious and fast gluten-free pizza crust.


Read more + get the recipe >>

107 year old blogs

Thought i'd share this. Enjoy.

107 year old blog

Apparently she was really thin all through her life too. Which you can actually see in the photos. In her fourth post they mike and ollie talk about longevity.


Mike

"You don’t eat much, do you?"

Olive (centenarian)

"Not much."

Mike

"I used to know a centenarian called Roy Fox who lived round here. He was famous for two things. He was still driving at 100 and he knew the secret of long life, at least he thought he did."

Chloe

"What was it?"

Mike

"He chewed his food really slowly. He was convinced this was the reason for his reaching 100 and he may have been right because, his eating slowly meant that he was full quicker and so he actually ate less. So, Ollie, you do the same thing, you eat very little and that explains why you are still with us without a doubt!"

Website, progress and stuff...

Nothing to report so far. Everything seems to be going good... I'm back in work tomorrow and the rest of the week :) I feel much more upto going to work also, as before I didn't because of quite a few probs. However, things will hopefully get better still after I see the ENT doctor. I don't know what I should expect on the first appointment, he probably just wants some backround info and stuff, I'm not at all sure if the doctor will check up my nose and stuff with an endoscope?

I hope everyone is doing well. I hope I provided at least some valuable information during this whole thing over the last few months. Best to prevent things that learn from mistakes :D My website will be updated shortly with lots of new info, links to articles, videos, audio, documentary, CR general info and more. Just gotta get through the rest of college first.

Thursday, May 3, 2007

picture update

Nothing interesting happen today... another nice sunnny day, just finishing and getting all my college folders sorted to be moderated. Heres a pic I took, which I thought I'd share as I don't think i've put one up of more than just my head in the photo lol. Click enlarge picture.