Adiponectin ^ SIRT1 > Healthier aging?

I posted a paper on centenarians a while back on the CR lists suggesting that Adiponectin is worth measuring in long term calorie restrictors. I’m unaware that this has been measured at WUSTL? If it was could you share the results? Anyway, an old paper on centenarians looked at various aspects of their health, and it hypothesised that adiponectin plays a crucial role in the their health and longevity of these centenarians. They had three groups and only the centenarians had a statistically significant higher level of this adipocytokine, despite have a control group who were around the same BMI. From Paper [1] “Mean concentration of plasma adiponectin in female centenarians was almost twice as high as those in BMI-matched female controls (20.3 ± 7.4, 10.8 ± 3.9, P < 0.001, respectively), and also higher than those in elderly controls (P < 0.001)”. SIRT1 wasn’t actually measured in this study but [2] shows that Adiponectin induces expression of the SIRT1 Protein. There could be a possibility that because of the significantly higher level of adiponectin, these centenarians also had higher levels of SIRT1, (which is thought to be important in mammalian aging) and thus increased longevity. Centenarians also maintained a low BMI, but this could be the fact that they were suffering from age related muscle loss, as what happens with age. Although in the case of CR, it is sort of attenuated, in rodents at least. Calorie restriction is also thought to increase adipoectin in both rodents and humans under calorie restriction, and even those that have AN.


[1]Yasumichi Arai,1 Susumu Nakazawa,1 Toshio Kojima,3 Michiyo
Takayama,1 Yoshinori Ebihara,1 Ken-ichirou Shimizu,5 Ken Yamamura,1 Satoki Homma,1 Yasunori Osono,6 Yasuyuki Gondo,2 Yukie Masui,2 Hiroki Inagaki,2 Kohji Kitagawa4 and Nobuyoshi Hirose1 High adiponectin concentration and its role for longevity in female centenarians Geriatr Gerontol Int 2006; 6: 32–39


[2] Anthony E. Civitarese*, Stacy Carling, Leonie K. Heilbronn,
Mathew H. Hulver, Barbara Ukropcova, Walter A. Deutsch, Steven R. Smith, Eric Ravussin Calorie Restriction Increases Muscle Mitochondrial Biogenesis in Healthy Humans
PLoS Med. 2007 Mar 6;4(3):e76
PMID: 17341128