If you haven't got real player you can download it for free. Just do a google search... it's worth it to watch these two :) When you go to the video make sure you click on play in a stand alone player because some things will be much harder to see if you try watching it in the embedded real player.
From Worms to Mammals: Genes that Control the Rate
Changing a single gene in the small roundworm C. elegans can double its lifespan. This gene encodes an insulin/IGF-1 like receptor, which indicates that aging is regulated hormonally. By manipulating genes and cells, we have now been able to extend the lifespan and period of youthfulness of healthy, active C. elegans by six times
VIDEO HERE
Sirtuins, Aging and Disease
SIR2 and related genes are NAD-dependent deacetylases that slow aging in yeast, C. elegans, and Drosophila. In yeast and flies, SIR2 genes are also involved in the longevity conferred by dietary or calorie restriction (CR). The mammalian SIRT homologs are involved in changes in stress resistance and metabolism known to be associated with CR. The CR diet not only extends life span in rodents, but also protects against many diseases of aging, including diabetes, cardiovascular disease, neurodegenerative disease, cancer and osteoporosis. In this talk, I will describe recent findings in the lab regarding SIRT1 function in specific mammalian tissues and in specific disease models. Our findings indicate a diverse array of effects exerted by SIRT1 in mammals.
VIDEO HERE
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