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Wednesday, January 31, 2007

Monkey Studies 2

This monkey C58 was sent from India, and then put on a Calorie Restriction diet (30%). I believe he wasn't put on CR until late in his life, and he lived to 41 years (123 human years). Apparently he is the oldest Rhesus monkey documented (?)

One thing I forgot to mention is that in the NIA study the monkeys were throwing away their food, both ad lib and calorie restricted monkeys... apparently it is due to being in a depressive state. I mean they are locked up in those cages for so long, who wouldn't be!?!? So this could be an important factor. It might just be that the University of Wisconsin studies are better done and thats why they are showing increase in longevity. Answers will come soon, but not soon enough.

What about other recent studies? There was one done that was more of a weight maintaining study and had their ad lib eat what they want when they want. The results... the ad lib group lived to 23 and the 30% CR group lived, wait, 30% longer! (30 years) and that is equivalent to a group of humans living on average to 90 years.

I believe there was another study "Mortality and Morbidity in Laboratory-maintained Rhesus Monkeys and Effects of Long-term Dietary Restriction". Again this compared true ad lib vs CR obesity avoidance monkey diet. The ad lib monkeys lived on average to 25 while the calorie restricted monkeys lived to 32 on average. There were 117 monkeys, 8 were CR'd, and 109 ate however much they wanted. In human equivalent years 32 years is around 96 human years.

Both of those are OBESITY AVOIDANCE studies and not true life extending CR studies. Whatever reason the NIA are not seeing as a good results as the UW studies is yet to be determined. Things might shift back in favour of CR at some point. There was a learning curve for adult onset CR in rodents, and maybe so for monkeys.

Monkeys and Human CRers that have been on CR for long term look IMO significantly younger than their ages. But any reasonably healthy diet would probably keep one looking younger for a bit longer.

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