Statins are significantly associated with increased myositis risk.

This study was published in the Journal of Clinical Epidemiology 2007 Aug;60(8):812-8

Study title and authors:
Statin and statin-fibrate use was significantly associated with increased myositis risk in a managed care population.

McClure DL, Valuck RJ, Glanz M, Murphy JR, Hokanson JE.
Clinical Research Unit, Kaiser Permanente Colorado, Denver, CO 80237-8066, USA. david.1.mcclure@kp.org

This study can be accessed at: http://www.ncbi.nlm.nih.gov/pubmed/17606177

This four year study quantified the risk of myositis (myositis cases were defined as creatine kinase levels more than 10x upper limit of normal and a myopathy (muscle disease) diagnosis) associated with statin and fibrate drug use within a managed care organization population.

The study found:
(a) Statin users had a 180% increased risk of myositis compared to non-users.
(b) Statin-fibrate combination users had a 810% increased risk of myositis compared to non-users.

The results from this study show that statins, with or without fibrates, were significantly associated with increased myositis risk.